業績
| 原著論文 | |
| 1 | Miyazaki Y, Katanasaka Y, Tsutsui Y, Sunagawa Y, Funamoto M, Shimizu K, Shimizu S, Sari N, Yamakage H, Satoh-Asahara N, Toyama K, Suzuki M, Shimizu A, Wada H, Hasegawa K, Morimoto T. A randomized placebo-controlled, double-blind study of Kosen-cha, a polymerized catechin-rich green tea, for obesity in pre-obese Japanese subjects. BPB report 3(6), 202-207, 2020. |
| 2 | Sunagawa Y, Okamura N, Miyazaki Y, Shimizu K, Genpei M, Funamoto M, Shimizu S, Katanasaka Y, Morimoto E, Yamakage H, Komiyama M, Satoh-Asahara N, Wada H, Suzuki M, Hasegawa K, Morimoto T. Effects of products containing Bacillus subtilis var. natto on healthy subjects with neck and shoulder stiffness, a double-blind, placebo-controlled, randomized crossover study. Biol Pharm Bull. 41(4): 504-509, 2018. |
| 3 | Montel V, Suzuki M, Galloy C, Mose ES, Tarin D. Expression of melanocyte-related gene in human breast cancer and its implications. Differentiation. 78(5):283-91, 2009. |
| 4 | Suzuki M, Mose E, Galloy C, Tarin D. Osteopontin gene expression determines spontaneous metasttic performance of orthotopic human breast cancer xenografts. Am J Pathol. 171(2):682-692, 2007. |
| 5 | Suzuki M, Tarin D. Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: Clinical implications. Mol Oncol. 1:172-180, 2007. |
| 6 | Suzuki M, Montel V, Tarin D. Dormant cancer cells retrieved from metastasis-free organs regain tumorigenic and metastatic potency. Am J Pathol. 169(2):673-81, 2006. |
| 7 | Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. Suppression of lipopolysaccharide-induced cytokine production of gingival fibroblasts by a soybean, Kunitz trypsin inhibitor. J Periodontal Res. 40(6):461-8, 2005. |
| 8 | Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yague T, Inagaki K, Kondo T, Kurita N, Yamada Y, Sado T, Kitanaka T, Suzuki M, Kanayama N, Terao T. A soy bean Kunits trypsin inhibitor reduces tumor necrosis factor- production in ultoraviolet-exposed primary human keratinocytes. Exp Dermatol. 14(10):765-74, 2005. |
| 9 | Omatsu K, Kobayashi T, Murakami Y, Suzuki M, Ohashi R, Sugimura M, Kanayama N. Phosphatidylserine/phosphatidylcholine microvesicles can induce preeclampsia-like changes in pregnant mice. Semin Thromb Hemost. 31(3):314-20, 2005. |
| 10 | Murakami Y, Kobayashi T, Omatsu K, Suzuki M, Ohashi R, Matsuura T, Sugimura M, Kanayama N. Exogenous vascular endothelial growth factor can induce preeclampsia-like symptoms in pregnant mice. Semin Thromb Hemost. 31(3):307-13, 2005. |
| 11 | Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Reduced syndecan-1 expression stimulates heparin-binding growth factor-mediated invasion in ovarian cancer cells in a urokinase-independent mechanism. Oncol Rep. 14(2):449-57, 2005. |
| 12 | Inagaki K, Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Kondo T, Kurita N, Kitanaka K, Yamada Y, Sakamoto Y, Suzuki M, Kanayama N, Terao T. Suppression of urokinase expression and invasion by a soybean kunitz trypsin inhibitor is mediated through inhibition of Src-dependent signaling pathways. J Biol Chem. 280(36):31428-37, 2005. |
| 13 | Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol. 131(8):527-38, 2005. |
| 14 | Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. Dietary supplementation of soybean kunitz trypsin inhibitor reduces lipopolysaccharide-induced lethality in mouse model. Shock. 23(5):441-447, 2005. |
| 15 | Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Plasma bikunin as a favorable prognostic factor in ovarian cancer. J Clin Oncol. 23(7):1463-72, 2005. |
| 16 | Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages. J Infect Dis. 191(6):930-8, 2005. |
| 17 | Yagyu T, Kobayashi H, Matsuzaki H, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation. J Clin Endocrinol Metab. 90(5):3017-21, 2005. |
| 18 | Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Bikunin down-regulates heterodimerization between CD44 and growth factor receptors and subsequently suppresses agonist-mediated signaling. J Cell Biochem. 94(5):995-1009, 2005. |
| 19 | Matsuzaki H, Kobayashi H, Yagyu T, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages. Clin Diagn Lab Immunol. 11(6):1140-7, 2004. |
| 20 | Suzuki M, Kobayashi H, Tanaka Y, Kanayama N, Terao T. Reproductive failure in mice lacking inter-alpha-trypsin inhibitor (ITI)--ITI target genes in mouse ovary identified by microarray analysis. J Endocrinol. 183(1):29-38, 2004. |
| 21 | Yagyu T, Kobayashi H, Wakahara K, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-beta and subsequently suppresses TGF-beta signalings. FEBS Lett. 576(3):408-16, 2004. |
| 22 | Kobayashi H, Fukuda Y, Yoshida R, Kanada Y, Nishiyama S, Suzuki M, Kanayama N, Terao T. Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model. Int J Cancer. 112(3):519-24, 2004. |
| 23 | Wakahara K, Kobayashi H, Yagyu T, Matsuzaki H, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T. Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells. J Cell Biochem. 93(3):437-53, 2004. |
| 24 | Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Suzuki M, Terao T. Upregulation of bikunin in tumor-infiltrating macrophages as a factor of favorable prognosis in ovarian cancer. Gynecol Oncol. 94(3):725-34, 2004. |
| 25 | Kobayashi H, Suzuki M, Terao T. A soybean Kunitz trypsin inhibitor suppresses ovarian cancer cell invasion by blocking urokinase upregulation. Clin. Exp. Metastasis 21(2):159-66, 2004. |
| 26 | Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T. Bikunin plus paclitaxel markedly reduce tumor burden and ascites in mouse model of ovarian cancer. Int. J. Cancer 110(1): 134-139, 2004. |
| 27 | Tanaka Y, Kobayashi H, Suzuki M, Hirashima Y, Kanayama N, Terao T. Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis. Int. J. Cancer 109(3): 336-47, 2004. |
| 28 | Kobayashi H, Yagyu T, Inagaki K, Kondo T, Suzuki M, Kanayama N, Terao T. Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer. Cancer 100(4): 869-877, 2004. |
| 29 | Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin CY, Dickson RB, Terao T. Inhibition of tumor invasion by genomic downregulation of matriptase through suppression of activation of receptor-bound pro-urokinase. J. Biol. Chem. 279(15): 14899-14908, 2004. |
| 30 | Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Terao T. Transforming growth factor-beta 1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells. J. Biol. Chem. 279(10): 8567-8576, 2004. |
| 31 | Kobayashi H, Suzuki M, Kanayama N, Terao T. Genetic down-regulation of phoshoinositide-3-kinase by Bikunin correlates with suppression of invasion and metastasis in human ovarian cancer HRA cells. J. Biol. Chem. 279(8): 6371-6379, 2004. |
| 32 | Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Suzuki M, Yamakawa T, Morishita H, Terao T. Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma. Cancer 98(2): 424-430, 2003. |
| 33 | Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. Transforming growth factor-beta1 (TGF-beta 1) produced by ovarian cancer cell line HRA stimulates attachment and invasion through an upregulation of plasminogen activator inhibitor type-1 (PAI-1) in human peritoneal mesothelial cells. J. Biol. Chem. 278(29): 26793-802, 2003. |
| 34 | Kobayashi H, Suzuki M, Hirashima Y, Terao T. The protease inhibitor bikunin, a novel anti-metastasis agent. Biol. Chem. 384(5): 749-754, 2003. |
| 35 | Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T. Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin. Int. J. Cancer 104(3) 289-302, 2003. |
| 36 | Sun GW, Kobayashi H, Suzuki M, Kanayama N, Terao T. Follicle-stimulation hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phoshatidylinositol-dependent kinase/Akt in rat granulose cells. Endocrinology 144(3): 793-801, 2003. |
| 37 | Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T. Bikunin target genes in ovarian cancer cells identified by microarray analysis. J. Biol. Chem. 278(17): 14640-46, 2003. |
| 38 | Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. A Kunitz-type protease inhibitor, bikunin, inhibits ovarian cancer cell invasion by blocking calcium-dependent transforming growth factor (TGF)-beta 1 signaling cascade. J Biol. Chem. 278(10):7790-9, 2002. |
| 39 | Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T. CD44 stimulation by fragmented hyaluronic acid induces upregulation of urokinase-type plasminogen activator and its receptor and subsequently facilitates invasion of human chondrosarcoma cells. Int. J. Cancer 102(4): 379-89, 2002. |
| 40 | Sun GW, Kobayashi H, Suzuki M, Kanayama N, Terao T. Production of cartilage link protein by human granulose-lutein cells. J Endocrinol. 175(2): 505-15, 2002. |
| 41 | Tanaka Y, Kobayashi H, Suzuki M, Kanayama N, Suzuki M, Terao T. Thymidine phosphorylase expression in tumor-infiltrating macrophage may be correlated with poor prognosis in uterine endometrial cancer. Human Pathology 33(1): 1105-13, 2002. |
| 42 | Sun GW, Kobayashi H, Suzuki M, Kanayama N, Terao T. Link protein as an enhancer of cumulus cell-oocyte complex expansion. Mol. Reprod. Dev. 63(2):223-31, 2002. |
| 43 | Suzuki M, Kobayashi H, Kanayama N, Nishida T, Takigawa M, Terao T. CD44 stimulation by fragment hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells. Biochim. Biophys. Acta. 159(1-3):37-44, 2002. |
| 44 | Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T. Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade. Eur. J. Biochim. 269(16); 3945-57, 2002. |
| 45 | Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, Terao T. Kunitz-type protease inhibitor bikunin disrupts phorbor ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. J. Biol. Chem. 277(10): 8022-32, 2002. |
| 46 | Suzuki M, Kobayashi H, Kageyama S, Shibata K, Fujie M, Terao T. Excretion of bikunin and its fragments in the urine of patients with renal stones. J. Urol. 166(1): 268-74, 2001. |
| 47 | Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Terao T. Structure and function analysis of urinary trypin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins. Biochem. Biophys. Acta. 1547(1): 26-36, 2001. |
| 48 | Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Fujie M, Nishida T, Takigawa M, Terao T. Characterization of binding properties of urinary trypsin inhibitor to cell-associated binding sites on human chondrosarcoma cell line HCS-2/8. J. Biol. Chem. 276(17): 13650-6, 2001. |
| 49 | Kobayashi H, Suzuki M, Tanaka Y, Hirashima Y, Terao T. Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C-and MEK/ERK/c-Jun-dependent signaling pathways. J. Biol. Chem. 276(3): 2015-22, 2001. |
| 50 | Kobayashi H, Suzuki M, Sun GW, Hirashima Y, Terao T. Suppression of urokinase-type plasminogen activator expression from human ovarian cancer cells by urinary trypsin inhibitor. Biochim. Biophys. Acta. 1481(2): 310-6, 2000. |
| 51 | Katanasaka Y, Sunagawa Y, Miyazaki Y, Funamoto M, Shimizu S, Shimizu K, Yamakage H, Satoh-Asahara N, Toyama K, Sabashi T, Suzuki M, Hamabe-Horiike T, Komiyama M, Wada H, Mori K, Hasegawa K, Morimoto T. Ameliorating prediabetic subject status via fermented tea supplementation: A randomized, double-blind, parallel-group comparison study. Journal of Functional Foods 97: 105257-63, 2022. |