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ホーム  > 診療科  > 病理診断科

病理診断科

診療科責任者

小川 博 部長

概要または責任者から一言

日常診療(特に腫瘍領域)において、正しい病理診断が正しい治療の第一歩となっています。当科では正確な診断を常に心がけ、組織診(生検例、手術例)、迅速病理診断、細胞診、病理解剖に取り組んでいます。病理診断が難しい症例については、臨床医との情報交換や病理学的追加検索(追加切り出し、深切り標本作製、免疫染色など)により解決を図っています。また、一部の診断困難な症例や特殊な症例の場合には、国内外の専門病理医にコンサルテーションするように努めています。

研修医の方

初期研修プログラムについてはこちら(診療科別 初期研修プログラム)をご覧ください。
後期研修プログラムについてはこちら(後期研修診療科別プログラム)をご覧ください。

主な診療・専門領域

腫瘍病理、消化管病理、婦人科病理

治療成績

2009年2010年2011年2012年2013年2014年2015年2016年2017年2018年
組織診件数6,7786,4876,7017,1417,5396,9316,5686,6866,5566,539
迅速診断件数489505468669459491521544525475
細胞診件数16,94619,49222,30119,69914,85915,8827,8895,9284,2163,921
病理解剖件数2029191913219211313

年報・実績について

年報、学術業績については下記PDFをご覧ください。

年報データ

学術業績データ

スタッフ

氏名職位卒年専門領域・認定医・専門医
小川博部長1985年日本病理学会認定病理専門医
日本病理学会病理専門医研修指導医
日本病理学会学術評議員
高橋青志郎医長2002年日本病理学会認定病理専門医
日本病理学会病理専門医研修指導医
日本臨床細胞学会認定細胞診専門医
日本臨床細胞学会教育研修指導医

他、非常勤病理医2名、非常勤病理コンサルタント1名、臨床検査技師6名(うち細胞検査士3名)、写真技師1名(兼任)

English

Department of Pathology, Seiriei Mikatahara Hospital

In the clinical practice, especially in oncology, the accurate pathological diagnosis is the first step for the adequate treatment. We handle biopsy, surgical, frozen, cytology, and autopsy specimens with the greatest care. For precise diagnoses, not only clinical information, deep sections, and immunohistochemical examinations are used, but also consultation with expert pathologists.

Staff

Hiroshi Ogawa, MD (Tumor Pathology)
Seishiro Takahashi, MD, PhD (Genitourinary Pathology)
Ayse Ayhan, MD, PhD (Gynecologic Pathology)
Kazuya Shinmura, MD, PhD (Molecular Pathology)
Yuzo Endo, MD, PhD (Renal Pathology)

Activity of Anatomic Pathology

2009201020112012201320142015201620172018
Biopsy and Surgical Cases6,7786,4876,7017,1417,5396,9316,5686,6866,5566,539
Frozen Section Cases489505468669459491521544525475
Cytology Cases16,94619,49222,30119,69914,85915,8827,8895,9284,2163,921
Autopsy Cases2029191913219211313

Contact

Hiroshi Ogawa, MD
Department of Pathology, Seirei Mikatahara Hospital
Mikatahara 3453, Hamamatsu, 433-8558
Phone +81 53 436 1251
Facsimile +81 53 437 4600
E-mail:h-ogawa@sis.seirei.or.jp

References

Mino N, Yoshii N, Okabe H, Takahashi S, Ogawa H, Tanahashi M, Niwa H, Muto S
A case of pulmonary pleomorphic carcinoma discovered during optional low-dose computed tomography screening and resected at the early stage
Ningen Dock International 5 : 38-43 2018

Kuhn E, Ayhan A
Diagnostic immunohistochemistry in gynaecological neoplasia: a brief survey of the most common scenarios
J Clin Pathol 71 : 98-109 2018

Noe M, Ayhan A, Wang TL, Shih IM
Independent development of endometrial epithelium and stroma within the same endometriosis
J Pathol 245 : 265-269 2018

Yagi H, Takahashi S, Shinmura K, Iwashita T, Ogawa H
Mesothelial/monocytic incidental cardiac excrescence with bone marrow
Pathol Int 68 : 436-438 2018

Ayhan A, Kuhn E, Wu RC, Ogawa H, Bahadirli-Talbott A, Mao TL, Sugimura H, Shih IeM, Wang TL
CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis
Mod Pathol 30(2) : 297-303 2017

Inoue Y, Yoshimura K, Kurabe N, Kahyo T, Tanahashi M, Ogawa H, Inui N, Funai K, Niwa H, Suda T, Sugimura H
Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer
Oncotarget (5) : 8738-8751 2017

Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Noe M, Horlings HM, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu RC, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Cohen JD, Wong F, Hasanovic A, Orr N, Zhang M, Popoli M, McMahon W, Wood LD, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang TL, Vogelstein B, Yong PJ, Huntsman DG, Shih IeM
Cancer-associated mutations in endometriosis without cancer
N Engl J Med 376(19) : 1835-1848 2017

Yoshimura K, Inoue Y, Mori K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H
Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-small cell lung cancer
Genes Chromosomes Cancer 56(7) : 570-581 2017

Shinmura K, Kato H, Kawanishi Y, Igarashi H, Inoue Y, Yoshimura K, Nakamura S, Fujita H, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma
Mol Carcinog 56(8) : 1984-1991 2017

Labidi-Galy SI, Papp E, Hallberg D, Niknafs N, Adleff V, Noe M, Bhattacharya R, Novak M, Jones S, Phallen J, Hruban CA, Hirsch MS, Lin DI, Schwartz L, Maire CL, Tille JC, Bowden M, Ayhan A, Wood LD, Scharpf RB, Kurman R, Wand TL, Shih IeM, Karchin R, Drapkin R, Velculescu VE
High grade serous ovarian carcinomas originate in the fallopian tube
Nature Commun 8(1) : 1093 2017

Wu RC, Veras E, Lin J, Gerry E, Bahadirli-Talbott A, Baras A, Ayhan A, Shih IeM, Wang TL
Elucidating the pathogenesis of synchronous and metachronous tumors in a woman with endometrioid carcinomas using a whole-exome sequencing approach
Cold Spring Harb Mol Case Stud 3 : a001693 2017

Inoue Y, Matsuura S, Yoshimura K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Maeda M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H
Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function in gastric, lung, and esophageal cancer cells
Cancer Sci 106(8) : 1701-1714 2017

Asano Y, Fujita H, Ogino K, Kimura T, Yamakawa J, Maruyama S, Kunimoto Y, Ogawa H, Ogura H, Tochikubo J
Surgery for pancreatic metastasis of neuroendocrine carcinoma of the breast: a case report
Int J Clin Exp Med 10(9) : 13844-13849 2017

Celik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Ozdemirli M, Ayhan A, Rudek MA, Toretsky JA, Uren A
Ezrin Inhibition Up-regulates Stress Response Gene Expression
J Biol Chem 291(25):13257-13270 2016

Inoue Y, Yoshimura K, Mori K, Kurabe M, Kahyo T, Mori H, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Suda T, Sugimura H
Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer
Oncotarget 7(22) : 32113-32128 2016

Kuhn E, Wang T-L, Doberstein K, Bahadirli-Talbott A, Ayhan A, Sehdev AS, Drapkin R, Kurman RJ, Shih IeM
CCNE1 amplification and centrosome number abnormality in serous tubal intraepithelial carcinoma: further evidence supporting its role as a precursor of ovarian high-grade serous carcinoma
Mod Pathol 29(10):1254-1261 2016

Jung JG, Shih IeM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Fader AN, Selleri L, Wang TL
Ovarian cancer chemoresistance relies on the stem cell reprogramming factor PBX1
Cancer Res 76(21):6351-6361 2016

Shinmura K, Kato H, Igarashi H, Inoue Y, Nakamura S, Du C, Kurachi K, Nakamura T, Ogawa H, Tanahashi M, Niwa H, Sugimura H
CD44-SLC1A2 fusion transcripts in primary colorectal cancer
Pathol Oncol Res 21(3):759-764 2015

Shinmura K, Igarashi H, Kato H, Koda K, Ogawa H, Takahashi S, Otsuki Y, Yoneda T, Kawanishi Y, Funai K, Takayama T, Ozono S, Sugimura H
BSND and ATP6V1G3:Novel Immunohistochemical Markers for Chromophobe Renal Cell Carcinoma
Medicine 94(24):e989 2015

Mao TL, Ayhan A, Kuo KT, Lin MC, Tseng LH, Ogawa H
Immunohistochemical study of endometrial high-grade endometrioid carcinoma with or without a concurrent low-grade component:implications for pathogenetic and survival differences
Histopathology 67 (4):474-482 2015

Ayhan A, Mao TL, Rahmanto YS, Zeppernick F, Ogawa H, Wu RC, Wang TL, Shih IeM
Increased proliferation in atypical hyperplasia/endometrioid intraepithelial neoplasia of the endometrium with concurrent inactivation of ARID1A and PTEN tumour suppressors
J Pathol: Clin Res 1(3):186-193 2015

Yu Y, Gaillard S, Phillip JM, Huang TC, Pinto SM, Tessarollo NG, Zhang Z, Pandey A, Wirtz D, Ayhan A, Davidson B, Wang TL, Shih IeM
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced ytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules
Cancer Cell 28(1):82-96 2015

Wu RC, Ayhan A, Maeda D, Kim KR, Clarke BA, Shaw P, Chui MH, Rosen B, Shih IeM, Wang TL
Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy
Pathol 232(4): 473-81, 2014

Kuhn E, Ayhan A, Shih IeM, Seidman JD, Kurman RJ
The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis
Mod Pathol 27(2): 231-7, 2014

Kuhn E, Ayhan A, Bahadirli-Talbott A, Zhao C, Shih IeM
Molecular characterization of undifferentiated carcinoma associated with endometrioid carcinoma
Am J Surg Pathol 38(5): 660-5, 2014

Shinmura K, Kato H, Matsuura S, Inoue Y, Igarashi H, Nagura K, Nakamura S, Maruyama K, Tajima M, Funai K, Ogawa H, Tanahashi M, Niwa H, Sugimura H
A novel somatic FGFR3 mutation in primary lung cancer
Oncol Rep 31(3): 1219-24, 2014

Shinmura K, Kahyo T, Kato H, Igarashi H, Matsuura S, Nakamura S, Kurachi K, Nakamura T, Ogawa H, Funai K, Tanahashi M, Niwa H, Sugimura H
RSPO fusion transcripts in colorectal cancer in Japanese population
Mol Biol Rep 41(8): 5375-84, 2014

Shinmura K, Igarashi H, Kato H, Kawanishi Y, Inoue Y, Nakamura S, Ogawa H, Yamashita T, Kawase A, Funai K, Sugimura H
CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the lung
Dis Markers 2014: 619273, 2014

Takahashi S, Yoshida E, Sakanishi Y, Tohyama N, Ayhan A, Ogawa H
Congenital multiple intrahepatic portosystemic shunt: an autopsy case
Int J Clin Exp Pathol 7(1): 425-431, 2014

Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H, Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, Sugimura H
SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers
Sci Rep 3: 3012, 2013

Matsuura S, Shinmura K, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, Funai K, Kohno T, Suda T, Sugimura H
CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma
Oncol Rep 30(4):1675-1680, 2013

Kahyo T, Tao H, Shinmura K, Yamada H, Mori H, Funai K, Kurabe N, Suzuki M, Tanahashi M, Niwa H, Ogawa H, Tanioka F, Yin G, Morita M, Matsuo K, Kono S, Sugimura H
Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus
Carcinogenesis 34(11): 2531-2538, 2013

Mao TL, Ardighieri L, Ayhan A, Kuo KT, Wu CH, Wang TL, Shih IeM
Loss of ARID1A expression correlates with stages of tumor progression in uterine endometrioid carcinoma
Am J Surg Pathol 37(9): 1342-1348, 2013

Kuhn E, Ayhan A, Shih IeM, Seidman JD, Kurman RJ
Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium
Eur J Cancer 49(18): 3839-3849, 2013

Hoshino T, Hamada N, Seki A, Ogawa H
Two cases of myxoma of the external auditory canal
Auris Nasus Larynx 39(6):620-622, 2012

Ogawa K, Pitchakarn P, Suzuki S, Chewonarin T, Tang M, Takahashi S, Naiki-Ito A, Sato S, Takahashi S, Asamoto M, Shirai T
Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells
Cancer Sci 103(5):860-867, 2012

Wu CH, Mao TL, Vang R, Ayhan A, Wang TL, Kurman RJ, Shih IeM
Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A
Int J Gynecol Pathol 31(4):297-303, 2012

Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM
Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma
Int J Gynecol Cancer 22(8):1310-1315, 2012

Shinmura K、Tao H、Nagura K、Goto M、Matsuura S、Mochizuki T、Suzuki K、Tanahashi M Niwa H、Ogawa H、Sugimura H
Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma
Lung Cancer 71(1):19-27,2011

Shinmura K、Igarashi H、Goto M、Tao H、Yamada H、Matsuura S、Tajima M、
Matsuda T、Yamane A、Funai K、Tanahashi M、Niwa H、Ogawa H、Sugimura H
Aberrant expression and mutation-inducing activity of AID in human lung cancer
Ann Surg Oncol 18(7):2084-92, 2011

Arai Y, Shimizu S, Eimoto T, Shimizu S, Otsuki Y, Kobayashi H, Ogawa H, Travis WD
Peripheral pulmonary papillary/glandular neoplasms with ciliated cells and a component of well-differentiated adenocarcinoma: report of three tumours.
Histopathology 56(2): 265-269, 2010

Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H,
Niwa H, Shinmura K, Sugimura H
Secreted form of EphA7 in lung cancer.
Int J Oncol 36(3): 635-640, 2010

Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H, Morishima Y, Nakamura S
Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma.
Int J Hematol 91(3): 426-435, 2010

Khalique L, Ayhan A (Ogawa Ayse), Whittaker JC, Singh N, Jacobs IJ, Gayther SA, Ramus SJ
The clonal evolution of metastases from primary serous epithelial ovarian cancers.
Int J Cancer 124(7): 1579-1586, 2009

Kuo KT, Mao TL, Jones S, Veras E, Ayhan A (Ogawa Ayse), Wang TL, Glas R, Slamon D, Velculescu VE, Kuman RJ, Shih IeM
Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma.
Am J Pathol 174(5): 1597-1601, 2009

Veras E, Mao TL, Ayhan A (Ogawa Ayse), Ueda S, Lai H, Hayran M, Shih IeM, Kurman RJ
Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases.
Am J Surg Pathol 33(6): 844-853, 2009

Ayhan A (Ogawa Ayse), Kurman RJ, Yemelyanova A, Vang R, Logani S, Seidman JD,
Shih IeM
Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis.
Am J Surg Pathol 33(8): 1220-1224, 2009

Alexander-Sefre F, Nibbs R, Rafferty T, Ayhan A (Ogawa Ayse), Singh N, Jacobs I
Clinical value of immunohistochemically detected lymphatic and vascular invasions in clinically staged endometrioid endometrial cancer.
Int J Gynecol Cancer 19(6): 1074-1079, 2009

Widschwendter M, Apostolidou S, Jones AA, Fourkala EO, Arora R, Pearce CL, Frasco MA, Ayhan A (Ogawa Ayse), Zikan M, Cibula D, Iyibozkurt CA, Yavuz E, Hauser-Kronberger C, Dubeau L, Menon U, Jacobs IJ
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.
Int J Cancer 125(9): 2214-2218, 2009

Liu H, Takayama T, Ogawa H, Kai F, Sugiyama T, Aoki T, Harada M, Otsuka A,
Furuse H, Kurita Y, Mugiya S, Ushiyama T, Ozono S
Impact of thymidine phosphorylase-expressing macrophages for surgical margin in partial nephrectomy.
Urol Int 82(4): 388-393, 2009

Ramus SJ, Elmasry K, Luo Z, Gammerman A, Lu K, Ayhan A (Ogawa Ayse), Singh N, McCluggage WG, Jacobs IJ, Whittaker JC, Gayther SA
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.
Clin Cancer Res 14(18): 5840-5848, 2008

Vang R, Shih IeM, Salani R, Sugar E, Ayhan A (Ogawa Ayse), Kurman RJ
Subdividing ovarian and peritoneal serous carcinoma into moderately differentiated and poorly differentiated does not have biologic validity based on molecular genetic and in vitro drug resistance data.
Am J Surg Pathol 32(11): 1667-1674, 2008

Abe M, Ogawa H, Ayhan A (Ogawa Ayse)
The use of non-three-layer ultrasound in biopsy recommendation for premenopausal women.
Acta Obstet Gynecol Scand 87(11): 1155-1161, 2008

Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.
Lung Cancer 61(2): 163-169, 2008

Suzuki M, Kageyama S, Shinmura K, Okudela K, Bunai T, Nagura K, Igarashi H, Kiyose S, Mori H, Tao H, Goto M, Takamochi K, Mochizuki T, Suzuki K, Ohashi R, Ogawa H, Yamada T, Niwa H, Tsuneyoshi T, Sugimura H
Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and protein expression of EGFR in the carcinoma.
J Surg Oncol 98(6): 457-461, 2008

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