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ホーム  > 診療科  > 病理診断科

病理診断科

診療科責任者

小川 博 部長

概要または責任者から一言

日常診療(特に腫瘍領域)において、正しい病理診断が正しい治療の第一歩となっています。当科では正確な診断を常に心がけ、組織診(生検例、手術例)、迅速病理診断、細胞診、病理解剖に取り組んでいます。病理診断が難しい症例については、臨床医との情報交換や病理学的追加検索(追加切り出し、深切り標本作製、免疫染色など)により解決を図っています。また、一部の診断困難な症例や特殊な症例の場合には、国内外の専門病理医にコンサルテーションするように努めています。

研修医の方

初期研修プログラムについてはこちら(診療科別 初期研修プログラム)をご覧ください。
後期研修プログラムについてはこちら(後期研修診療科別プログラム)をご覧ください。

主な診療・専門領域

腫瘍病理、消化管病理、婦人科病理

治療成績

組織診件数迅速診断件数細胞診件数病理解剖件数
2006年8,97845610,46227
2007年8,2564757,43631
2008年7,15645313,09436
2009年6,77848916,94620
2010年6,48750519,49229
2011年6,70146822,30119
2012年7,14166919,69919
2013年7,53945914,85913
2014年6,93149115,88221
2015年6,5685217,8899
2016年6,6865445,92821
2017年6,5565254,21613

年報・実績について

年報、学術業績については下記PDFをご覧ください。

スタッフ

氏名職位卒年専門領域・認定医・専門医
小川博部長1985年日本病理学会認定病理専門医
日本病理学会病理専門医研修指導医
日本病理学会学術評議員
高橋青志郎医長2002年日本病理学会認定病理専門医
日本病理学会病理専門医研修指導医
日本臨床細胞学会認定細胞診専門医
日本臨床細胞学会教育研修指導医

他、非常勤病理医2名、非常勤病理コンサルタント1名、臨床検査技師6名(うち細胞検査士3名)、写真技師1名(兼任)

English

Department of Pathology, Seiriei Mikatahara Hospital

In the clinical practice, especially in oncology, the accurate pathological diagnosis is the first step for the adequate treatment. We handle biopsy, surgical, frozen, cytology, and autopsy specimens with the greatest care. For precise diagnoses, not only clinical information, deep sections, and immunohistochemical examinations are used, but also consultation with expert pathologists.

Staff

Hiroshi Ogawa, MD (Tumor Pathology)
Seishiro Takahashi, MD, PhD (Genitourinary Pathology)
Ayse Ayhan, MD, PhD (Gynecologic Pathology)
Kazuya Shinmura, MD, PhD (Molecular Pathology)
Yuzo Endo, MD, PhD (Renal Pathology)

Activity of Anatomic Pathology

Biopsy and Surgical CasesFrozen Section CasesCytology CasesAutopsy Cases
200392793871297328
200499244381249734
2005102364511054339
200689784561046227
20078256475743631
200871564531309436
200967784891694620
201064875051949229
201167014682230119
201271416691969919

Contact

Hiroshi Ogawa, MD
Department of Pathology, Seirei Mikatahara Hospital
Mikatahara 3453, Hamamatsu, 433-8558
Phone +81 53 436 1251
Facsimile +81 53 437 4600
E-mail:h-ogawa@sis.seirei.or.jp

References

Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IeM. Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma. Int J Gynecol Cancer 22(8):1310-1315, 2012

Wu CH, Mao TL, Vang R, Ayhan A, Wang TL, Kurman RJ, Shih IeM. Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A. Int J Gynecol Pathol 31(4):297-303, 2012

Ogawa K, Pitchakarn P, Suzuki S, Chewonarin T, Tang M, Takahashi S, Naiki-Ito A, Sato S, Takahashi S, Asamoto M, Shirai T. Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells. Cancer Sci 103(5):860-867, 2012

Hoshino T, Hamada N, Seki A, Ogawa H. Two cases of myxoma of the external auditory canal. Auris Nasus Larynx 39(6):620-622, 2012

Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer 71(1):19-27, 2011

Shinmura K, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Tajima M, Matsuda T, Yamane A, Funai K, Tanahashi M, Niwa H, Ogawa H, Sugimura H. Aberrant expression and mutation-inducing activity of AID in human lung cancer. Ann Surg Oncol 18(7):2084-92, 2011

Arai Y, Shimizu S, Eimoto T, Shimizu S, Otsuki Y, Kobayashi H, Ogawa H, Travis WD. Peripheral pulmonary papillary/glandular neoplasms with ciliated cells and a component of well-differentiated adenocarcinoma: report of three tumours. Histopathology 56(2): 265-269, 2010

Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H. Secreted form of EphA7 in lung cancer. Int J Oncol 36(3): 635-640, 2010

Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H, Morishima Y, Nakamura S. Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. Int J Hematol 91(3): 426-435, 2010

Khalique L, Ayhan A, Whittaker JC, Singh N, Jacobs IJ, Gayther SA, Ramus SJ. The clonal evolution of metastases from primary serous epithelial ovarian cancers. Int J Cancer 124(7): 1579-1586, 2009

Kuo KT, Mao TL, Jones S, Veras E, Ayhan A, Wang TL, Glas R, Slamon D, Velculescu VE, Kurman RJ, Shih IeM. Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol 174(5): 1597-1601, 2009

Veras E, Mao TL, Ayhan A, Ueda S, Lai H, Hayran M, Shih IeM, Kurman RJ. Cystic and adenofibromatous clear cell carcinomas of the ovary: distinctive tumors that differ in their pathogenesis and behavior: a clinicopathologic analysis of 122 cases. Am J Surg Pathol 33(6): 844-853, 2009

Ayhan A, Kurman RJ, Yemelyanova A, Vang R, Logani S, Seidman JD, Shih IeM. Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis. Am J Surg Pathol 33(8): 1220-1224, 2009

Alexander-Sefre F, Nibbs R, Rafferty T, Ayhan A, Singh N, Jacobs I. Clinical value of immunohistochemically detected lymphatic and vascular invasions in clinically staged endometrioid endometrial cancer. Int J Gynecol Cancer 19(6): 1074-1079, 2009

Widschwendter M, Apostolidou S, Jones AA, Fourkala EO, Arora R, Pearce CL, Frasco MA, Ayhan A, Zikan M, Cibula D, Iyibozkurt CA, Yavuz E, Hauser-Kronberger C, Dubeau L, Menon U, Jacobs IJ. HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study. Int J Cancer 125(9): 2214-2218, 2009

Liu H, Takayama T, Ogawa H, Kai F, Sugiyama T, Aoki T, Harada M, Otsuka A, Furuse H, Kurita Y, Mugiya S, Ushiyama T, Ozono S. Impact of thymidine phosphorylase-expressing macrophages for surgical margin in partial nephrectomy. Urol Int 82(4): 388-393, 2009

Ramus SJ, Elmasry K, Luo Z, Gammerman A, Lu K, Ayhan A, Singh N, McCluggage WG, Jacobs IJ, Whittaker JC, Gayther SA. Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer. Clin Cancer Res 14(18): 5840-5848, 2008

Vang R, Shih IeM, Salani R, Sugar E, Ayhan A, Kurman RJ. Subdividing ovarian and peritoneal serous carcinoma into moderately differentiated and poorly differentiated does not have biologic validity based on molecular genetic and in vitro drug resistance data. Am J Surg Pathol 32(11): 1667-1674, 2008

Abe M, Ogawa H, Ayhan A. The use of non-three-layer ultrasound in biopsy recommendation for premenopausal women. Acta Obstet Gynecol Scand 87(11): 1155-1161, 2008

Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H, Ogawa H, Sugimura H. EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer 61(2): 163-169, 2008

Suzuki M, Kageyama S, Shinmura K, Okudela K, Bunai T, Nagura K, Igarashi H, Kiyose S, Mori H, Tao H, Goto M, Takamochi K, Mochizuki T, Suzuki K, Ohashi R, Ogawa H, Yamada T, Niwa H, Tsuneyoshi T, Sugimura H. Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and protein expression of EGFR in the carcinoma. J Surg Oncol 98(6): 457-461, 2008

Singh N, Ayhan A, Menon U, Chin Lleong JA, Faruqi AZ, Gayther SA, Jacobs IJ. Grading of serous ovarian carcinoma: further evidence of a lack of agreement between conventional grading systems. Histopathology 52(3): 393-395, 2008

Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, Ogawa H, Nasuno H, Serizawa A, Kobayashi H. Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int 57(7): 421-429, 2007

Yamada M, Otsuki Y, Shimizu S, Tanioka F, Ogawa H, Kobayashi H. Cytological study of 20 cases of solid-papillary carcinoma of the breast. Diagn Cytopathol 35(7): 417-422, 2007

Okudela K, Suzuki M, Kageyama S, Bunai T, Nagura K, Igarashi H, Takamochi K, Suzuki K, Yamada T, Niwa H, Ohashi R, Ogawa H, Mori H, Kitamura H, Kaneko T, Tsuneyoshi T, Sugimura H. PIK3CA mutation and amplification in human lung cancer. Pathol Int 57(10): 664-671, 2007

Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A, Balkwill F. The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res 67(2):585-592, 2007

Khalique L, Ayhan A, Weale ME, Jacobs IJ, Ramus SJ, Gayther SA. Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J Pathol 211(3):286-295, 2007

Taftachi R, Ayhan A, Ekici S, Ergen A, Ozen H. Proliferating-cell nuclear antigen (PCNA) as an independent prognostic marker in patients after prostatectomy: a comparison of PCNA and Ki67. BJU Int 95(4):650-4, 2005

Baykal C, Guler G, Al A, Tulunay G, Ozer S, Yencilek R, Bulbul D, Ayhan A. Expression of the hepatocyte growth factor/scatter factor receptor in IUGR fetuses’ placentas: an immunohistochemical analysis. Fetal Diagn Ther 20(4):249-53, 2005

Ayhan A, Ertunc D, Tok EC, Ayhan A. Expression of the c-met in advanced epithelial ovarian cancer and its prognostic significance. Int J Gynecol Cancer 15(4):618-23, 2005

Unal VS, Ayhan A, Tokgozoglu MA. Proliferating-cell nuclear antigen index and nm23 expression in osteosarcoma in relation to disease-free survival and tumor grade. Saudi Med J 26(9):1475-7, 2005

Ayhan A, Baykal C, Demirtas E, Ayhan A, Yuce K. The influence of splenic metastases on survival in FIGO Stage IIIC epithelial ovarian cancer. Int J Gynecol Cancer 14 (1):51-56, 2004

Alexander-Sefre F, Singh N, Ayhan A, Thomas JM, Jacobs IJ. Clinical value of immunohistochemically detected lymphovascular invasion in endometrioid endometrial cancer. Gynecol Oncol 92 (2):653-59, 2004

Grimshaw M, Hagemann T, Ayhan A, Gilett CE, Binder C, Balkwill F. Endothelin and endothelin receptors in breast carcinoma. Cancer Res 64:2461-68, 2004

Ayhan A, Al A, Baykal C, Demirtas E, Ayhan A, Yuce K. Prognostic factors in FIGO stage IB cervical cancer without lymph node metastasis and the role of adjuvant radiotherapy after radical hysterectomy. Int J Gynecol Cancer 14 (2):286 -92, 2004

Ayhan A, Al A, Baykal C, Demirtas E, Yuce K, Ayhan A. A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinoma. Int J Gynecol Cancer 14(2):279-85, 2004

Alexander-Sefre F, Singh N, Ayhan A , Thomas JM, Jacobs IJ. Assessment of the depth of the myometrial invasion in Stage I endometrioid endometrial cancer using pancytokeratin immunohistochemistry. Int J Gynecol Cancer 14: 665-672, 2004

Ozyar E, Ayhan A, Korcum A, Atahan L. Prognostic role of Ebstein Barr Virus Latent Membran Protein-1 and Interleukin 10 expression in patients with nasopharyngeal carcinoma. Cancer Investigation 22(4):483-491, 2004

Brinkmann D, Ryan A, Ayhan A, McCluggage WG, Feakins R, Santibanez-Koref MF, Mein CA, Gayther SA. A molecular genetic and statistical approach for the diagnosis of dual-site cancers. J Natl Cancer Inst 96(19):1441-1446, 2004
Akin O, Agildere MM, Ersoy H, Ozen H, Ayhan A. Local staging of prostate cancer with endorectal surface coil MR imaging in a mid-field magnetic system. Clinical Imaging 27:47-51, 2003

Ramus SJ, Pharoah PD, Harrington P, Pye C, Werness B, Bobrow L, Ayhan A, Wells D, Fishman A, Gore M, DiCioccio RA, Piver MS, Whittmore AS, Ponder BA, Gayther SA. BRCA1/2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases. Cancer Res 63(2):417-23, 2003

Baykal C, Ayhan A, Al A, Yuce K, Ayhan A. Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas. Gynecol Oncol 88(2):123-9, 2003

Celenligil-Nazliel H, Palali A, Ayhan A, Ruacan S. Analysis of In Situ Proliferative Activity in Oral Gingival Epithelium in Patients With Xerostomia. J Periodontol 74:247-54, 2003

Baykal C, Ayhan A, Al A, Yuce K, Ayhan A. No relationship between FHIT expression and clinicopathologic prognostic parameters in early stage cervical carcinoma. Int J Gynecol Oncol 13(2):192-196, 2003

Andiran F, Kilinc K, Renda N, Ayhan A, Tanyel FC. Lipid peroxidation and extracellular matrix in normal and cirrhotic rat livers following 70% hepatectomy. Hepatogastroenterol 50(51):805-8, 2003

Topaloglu S, Abbasoglu O, Ayhan A, Sokmensuer C, Kilinc K. Antiapoptotic and protective effects of roscovitine on ischemia-reperfusion injury of the rat liver. Liver Int 23(4):300-7, 2003

Alexander-Sefre F, Singh N, Ayhan A, Salvenson HB, Wilbanks G, Jacobs IJ. Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol 56:786-88. 2003

Ekici S, Ayhan A, Erkan L, Bakkaloglu M, Ozen H. The role of the pathologist in the evaluation of radical prostatectomy specimens. Scand J Urol Nephrol 37:387-91, 2003

Baykal C, Demirtas E, Al A, Ayhan A, Yuce K, Tulunay G, Kose MF, Ayhan A. Comparison of HGF (Hepatocyte Growth Factor) levels of epithelial ovarian cancer cyst fluids with benign ovarian cysts. Int J Gynecol Oncol 13:771-75, 2003

Kerimoglu H, Kiratli H, Ayhan A, Soylemezoglu F, Bilgic S. Quantitative analysis of proliferation, apoptosis and angiogenesis in retinoblastoma and their association with the clinicopathological parameters. Jpn J Ophthalmol 47:565-571, 2003

Guler G, Sarac S, Uner A, Karabulut E, Ayhan A, Ogawa H. Prognostic value of CD44 variant 6 in laryngeal epidermoid carcinomas. Arch Otolaryngol Head Neck Surg 128(4):393-397, 2002

Eimoto T, Kitaoka M, Ogawa H, Niwa H, Murase T, Tateyama H, Inagaki H, Soji T, Wang HJ. Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. Histopathology 40(1):46-57, 2002

Inagaki H, Chan JKC, Ng JWM, Okabe M, Yoshino T, Okamoto M, Ogawa H, Matsushita H, Yokose T, Matsuno Y, Nakamura N, Nagasaka T, Ueda R, Eimoto T, Nakamura S. Primary thymic extranodal marginal-none B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol 160(4):1435-1443, 2002

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